Multi-omic sample analyses are not at the core of the 100,000 Genomes Project’s mission but are collected by the Genomic Medicine Centres (see Appendix 3 of the 100,000 Genomes Project Protocol). We recognise their potential to add depth to the clinical interpretation of the Project.
We know that several domains are interested in either using –omics data or developing methods and tools to allow –omics analyses.
No -omics samples were collected during the pilot phase of the Project, but are being collected as part of the main programme. We are interested to engage in dialogue with the GeCIP research community to identify analyses likely to have most impact on advancing disease diagnosis and treatment.
To achieve this, we will initiate a working group to bring together experts from multiple domains who can work with Genomics England on design and execution of the –omics pilot project. This project was put forward at the GeCIP Steering Committee Meeting on the 29th of March 2016.
Sample quality control strategies, required analytical platforms, suitable providers, and numbers of samples needed to conduct a meaningful pilot need to be determined. It is envisioned that core of –omics analyses will be performed in a centralised facility (eg UK Biobank), with potential for commissioning of specialised work to expert centres.
Please contact [email protected] if you have any comments or queries on -omics in the Project.
See this blog from Health Education England for more on omics.