Submitting a detailed research plan

Detailed research plans need to be submitted be each GeCIP domain in order for members of that domain to access the 100,000 Genomes Project dataset. One plan should be submitted per domain.

  1. Download the form 
  2. Return completed forms to chiefscientist@genomicsengland.co.uk. Please also use this email to contact us if you need any help or advice.
  3. Reviews of the detailed research plans are conducted by the Scientific Advisory Committee and the Access Review Committee.
    More on the review process can be found below.
  4. If successful, access to the Genomics England Research Environment will be granted. The plans will also be shared with the GeCIP Board.

Why we need detailed research plans

Resource allocation

Detailed plans will allow us to ensure that computing and research infrastructure, sample and know-how allocation are in place to facilitate the research each domain plans to carry out. They will also allow us to plan any shared core analyses.

Aligning research

Detailed research plans will help us ensure that research is aligned to the Project aims. They will also mean that research themes across GeCIP domains complement each other. They will help us ensure efficient resource allocation and minimal duplication of research effort.

Data access

The detailed research plans will form the basis of assessment by the Project’s Access Review Committee, to permit access to data.

Funding

The detailed research plans will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK who have representatives on the GeCIP Board. Read more about funding in GeCIP.

How are detailed research plans reviewed?

The review process assesses the scientific merit and the proposed uses of data. This is required in order to grant each GeCIP domain access to the Genomics England dataset.
Gecip research plansThe Office of the Chief Scientist will review the proposals to ensure:

• alignment of the proposed research with the 100,000 Genomes Project aims
• research themes are complementary across GeCIP domains
• Genomics England’s readiness to provide necessary resources to support proposed research
• Genomics England can provide guidance to the funding bodies to maximise opportunities for future grant awards.

Detailed research plans are first reviewed both internally by Genomics England staff and externally by one member of the Science Advisory Committee (SAC).

The application together with the reviews are then assessed by the SAC. The committee evaluates whether the proposed research adds value to the programme and is collaborative and inclusive. They also evaluate its feasibility given availability of bioinformatics resources and informatics infrastructure.

Once approved by the SAC, proposals are reviewed by the Access Review Committee (ARC) to assess whether ethical and responsible use of genomic and clinical data is proposed. They also determine whether it adheres to the acceptable uses of data access outlined in the 100,000 Genomes Project Protocol and includes patient and participants. This committee holds the final decision on each domain’s access to the database.

How is the detailed research plan different from the expression of interest / GeCIP domain application form?

To form a GeCIP domain, research groups were asked to complete a domain application form. Calls to form new GeCIP domains may be issued as and when needed.

Domain applications were reviewed by the Chief Scientist and the Science Advisory Board. Applicants were asked to demonstrate:

  • expertise in clinical reporting and data interpretation
  • scientific track-record, research plans, existing infrastructure and collaborations
  • opportunities for training.

Once a GeCIP domain application is approved the domain can formerly recruit members; however, they are not eligible for data access until they have submitted their detailed research plan and it has been approved by ARC.

For more information about forming a GeCIP domain, see the GeCIP guidance document (opens as PDF).