Submitting a detailed research plan
Detailed research plans need to be submitted in order to access the dataset. Rare disease and cross cutting GeCIP domains have been invited to submit their research plans. One plan should be submitted per domain. The submission process for cancer domains is not open yet in view of the recent initiation of the Cancer Main Programme.
Detailed research plans will be reviewed by the Scientific Advisory Committee and the Access Review Committee. More on the review process can be found below. If successful, access to Genomic England’s data centre will be granted. The plans will also be shared with the GeCIP Board.
Why we need detailed research plans
Detailed plans will allow us to ensure that computing and research infrastructure, sample and know-how allocation are in place to facilitate the research. They will also allow us to plan any shared core analyses.
Detailed research plans will help us ensure that research is aligned to the Project aims. They will also mean that research themes across GeCIP domains complement each other. They will help us ensure efficient resource allocation and minimal duplication of research effort.
The detailed research plans will form the basis of assessment by the Project’s Access Review Committee, to permit access to data.
The detailed research plans will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK who have representatives on the GeCIP Board. Read more about funding in GeCIP.
How are detailed research plans reviewed?
The review process assesses the scientific merit and the proposed uses of data. This is required in order to grant each GeCIP domain access to the Genomics England dataset.
The Office of the Chief Scientist will review the proposals to assure:
• Alignment of the proposed research with the 100,000 Genomes Project aims
• Complementarity of research themes across GeCIP domains
• Genomics England readiness to provide necessary resources to support proposed research
• Provide guidance to the funding bodies to maximise opportunities for future grant awards
Detailed research plans are first reviewed both internally by Genomics England staff and externally by one member of the Science Advisory Committee.
The application together with the reviews are then assessed by the Science Advisory Committee (SAC). SAC evaluate whether the proposed research adds value to the programme and is collaborative and inclusive. They also evaluate its feasibility given availability of bioinformatics resources and informatics infrastructure.
Once approved by the Science Advisory Committee, proposals are reviewed by the Access Review Committee (ARC) to assess whether ethical and responsible use of genomic and clinical data is proposed. They also determine whether it adheres to the acceptable uses of data access outlined in the 100,000 Genomes Project Protocol. This committee holds the final decision on each domain’s access to the database.
How is the detailed research plan different from the expression of interest / GeCIP domain application form?
To form a GeCIP domain, research groups were asked to complete a domain application form. Calls to form new GeCIP domains may be issued as and when needed.
Domain applications were reviewed by the Chief Scientist and the Science Advisory Board. Applicants are asked to demonstrate:
- Expertise in clinical reporting and data interpretation
- Scientific track-record, research plans, existing infrastructure and collaborations
- Opportunities for training
For more information about forming a GeCIP domain, see the GeCIP guidance document.