Enabling research

Approved researchers in our Genomics England Clinical Interpretation Partnership (GeCIP) domains will have access to de-identified data in the Project. They will research the causes of cancer, as well as develop new ways to diagnose and treat it.

Find out more about research in the 100,000 Genomes Project and how to apply to access the dataset.

Connect to researchers in your area of interest.


Research aims

Each research group (domain) in the Project has its own aims.

Many researchers will be studying the genetic changes that can lead to cancer by comparing the germline (normal) and somatic (tumour) genomes for each patient. Also, knowing how each participant progressed, i.e. whether they reacted well to treatment, will allow researchers to identify genetic signatures that influence how a tumour reacts to different treatments. This knowledge will help clinicians to identify ahead of time what treatment is going to be most effective.

Another exciting area of research is cell-free or circulating-tumour free DNA (cf/ctDNA). These short fragments of DNA are released into the bloodstream by dying tumour cells. Although in its infancy, testing ctDNA holds promise as a less invasive means for tumour diagnosis, prognosis and monitoring. The wealth of sequencing and clinical data in 100,000 Genomes Project should allow researchers to develop this approach.

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