Functional Cross-cutting GeCIP Domain

Description

The Functional Cross-cutting GeCIP domain is split into two different sub-domains: endogenous retroviruses and pathogens.

Endogenous Retroviruses

More than 10 years have passed since the first high quality, complete version of the human genome was published. The most-­studied part is the one that encodes for proteins (known as the exome) and accounts for 2‐3% of the total human genetic code. The rest of the genome is less understood.

Around half is composed of repetitive elements; one category of these, known as Endogenous Retroviruses (ERVs), is a remnant of ancient retroviral  infections of our ancient ancestors’ germ-cells, and make up around 5­‐8% of the human genome.

Our research explores potential health effects of human ERVs by combining bioinformatics and wet-lab approaches, with particular focus on trying to understand whether an association between particular ERV make up and incidence of disease can be found.

Pathogens

Over 30 research groups at the Norwich Research Park carry out research on bacteria. This work, linked to the BBSRC-funded The Genome Analysis Centre (TGAC), is generating discoveries that have applications in the fields of human health, pharmaceuticals, agriculture, food processing and environmental monitoring. We will apply our combined expertise to the identification of human pathogens using whole genome DNA sequence (WGS) data. As part of the Pan-Cancer ICGC  (International  Cancer  Genome Consortium) Project, a bioinformatics analysis pipeline (SEPATH) has already been set up within TGAC to carry out this work, demonstrating proof of principle.


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