Haematological malignancies refer to blood cancers that affect the blood, bone marrow, lymph and lymphatic system -systems that are all intimately connected by the circulatory (blood) and immune systems. Collectively they represent the fifth most common cancer in the UK, and while some patients respond well to treatment, the majority relapse and will ultimately die due to disease progression or therapy-related side-effects.
Genetic analyses have shown that haematological malignancies are not a single cancer, but a group of diseases with specific genetic features that affect how the blood cancer will behave. To better treat patients, and to develop new innovative targeted therapies, we need a comprehensive understanding of the genetics and biology of the various haematological malignancies; it is hoped that the 100,000 Genomes Project data will provide this insight.
You can find the full details of the research proposed by this domain in the Haematological Malignancies Detailed Research Plan.