There are about 10,000 cases of renal (kidney) cancer in the UK each year. Most cases are sporadic – they seem to happen randomly. Detection of early disease has increased, but in a quarter of patients their cancer has already spread from the kidney to other parts of the body when they are first diagnosed (called metastatic disease). Also, around a quarter of patients progress to metastatic disease following surgery to remove the tumour. Metastatic disease is incurable, and half of patients die within two years of diagnosis – and there about 4,000 deaths per year in the UK.
Despite advances in our understanding of kidney cancer, this has not translated into new medicines. Many patients receive treatment that is not effective and has considerable costs, both economic and in terms of side effects. One of the greatest challenges in this disease is to translate the ongoing increased understanding of biology into benefit for patients in the clinic. The Renal Cancer GeCIP domain will carry out research on the 100,000 Genomes Project dataset with this as their primary goal.