Testicular cancer is the commonest cancer and leading cause of death among young men, with >2,000 UK cases annually, and its frequency is increasing.
Testicular cancer is caused by uncontrolled growth in the testes and can occur in any of the different anatomical parts of the organ. The most frequent type of tumour (accounting for about 95% of all testicular tumours) are those of the germ cells – germ cell tumours (GCTs). Although most patients have good clinical outcomes, those in the highest risk group still have only a 50:50 chance of surviving cancer, despite decades of clinical trials. Furthermore, current chemotherapy treatments have substantial toxicities.
The Testicular Cancer GeCIP Domain want to take a ‘pan-omics’ approach to testicular cancer, that is using the wealth of data provided in the whole genome sequencing that will be produced by the 100,000 Genomes Project alongside all of the other research data available, to better identify the best treatments for each individual patient, and the patients who have the highest long-term risk.
You can find the full details of the research proposed by this domain in the Testicular Cancer Detailed Research Plan.