Upper gastrointestinal (UGI) cancer is caused by uncontrolled cell growth in the various organs of the upper gastrointestinal tract (commonly the oesophagus, stomach, pancreas, liver, and gallbladder).
There are approximately 41,304 UGI cancers diagnosed and 37,736 deaths in the UK per year. The majority of patients are only identified when they already have advanced disease and carrying out surgery for suitable cancers can often be challenging. Other treatments, such as the use of various drugs, have improved outcome but the benefit is negligible.
UGI cancers comprise a number of different conditions that have been grouped by virtue of anatomy and surgical approach. This leads to a mixture of different types of cancer, and therefore a wide range of research in the field. The overall aim of the Upper Gastrointestinal Cancer GeCIP Domain is to use the data resulting from the 100,000 Genomes Project to describe the landscape of UGI cancer and to allow improved understanding and treatment.