Genomics England will sequence ~40,000 whole cancer genomes and matched germline DNA over the next 2-‐3 years. This represents a considerably larger collection of whole cancer genomes than any that currently exist, and will be of similar magnitude to efforts planned elsewhere in the world in the same time frame, including from the NCI and ICGC-‐2. There will be a GeCIP domain for each tumour type analysed by Genomics England, focusing on the genomic and clinical aspects of their particular cancer. We propose to establish a GeCIP with an aim to understand patterns of germline and somatic variation in cancer genomes across tumour types. We believe such a GeCIP would be exploring fundamentally different questions to individual tumour type domains, and would produce data that would assist the individual domains in their interpretation of the genomic data.