Research topics in the 100,000 Genomes Project

GeCIP Domains are UK-led consortia of researchers, clinicians and trainees.

Each domain will work on improving the clinical application and interpretation of the data in the 100,000 Genomes Project. They will also carry out research to

  • Improve our understanding of genomic medicine and its application to healthcare
  • Improve our understanding of disease
  • Lead the way to developing new diagnostics and treatments.

Current Domains approved for data access

Several GeCIP domains have had their research plans approved. See the list and descriptions of their planned work.

Joining a Domain

Researchers can apply to join a GeCIP domain to work on the 100,000 Genomes Project dataset. More information about joining our research community.

List of current GeCIP Domains

This list will be updated throughout the project. Contact the lead researchers or NHS Genomic Medicine Centre representatives (links open in your email application):

DISEASE CATEGORY DOMAIN LEAD RESEARCHERS NHS GMC REPRESENTATIVE
Rare Disease Cardiovascular Prof Bernard KeavneyThe University of Manchester Dr Ed Blair Oxford University Hospitals NHS Foundation Trust
Endocrine and Metabolism Prof Stephen O’RahillyUniversity of Cambridge 
Gastroenterology and Hepatology Dr Patrick DuboisKing’s College Hospital, London
Dr Gideon HirschfieldUniversity of Birmingham
Dr Guy Chung-FayeKing’s College London
Richard Thompson King’s College London
Hearing and Sight Prof Andrew Webster (Sight) – University College London
Prof Maria Bitner-Glindzicz (Hearing) – University College London
Prof Graeme BlackManchester University
Immunology Prof Sophie HambletonNewcastle University
Haematology Prof Willem OuwehandUniversity of Cambridge
Dr Judith MarshKings College Hospital
Inherited Cancer Predisposition Dr Clare TurnbullQueen Mary University of London Marc Tischkowitz University of Cambridge
Musculoskeletal Prof Muhammad Kassim JavaidUniversity of Oxford Prof Muhammad Kassim JavaidUniversity of Oxford
Neurological Henry HouldenUniversity College London
Prof Patrick Chinnery  – University of Cambridge
Prof Huw MorrisUniversity College London
Paediatric Sepsis Prof Michael LevinImperial College
Paediatrics Dr Tim BarrettBirmingham University
Dr Phil BealesUniversity College London
Prof Maria Bitner-Glindzicz University College London
Renal Dr Daniel GaleNHS Dr Ania Koziell King’s College London
Respiratory Prof Eric AltonImperial College Tracy HigginsImperial College
Skin Prof John McGrathKing’s College London Prof Sean WhittakerKing’s College London
Cancer Breast Cancer Dr Nicholas TurnerInstitute of Cancer Research
Childhood Solid Cancers Prof Josef Vormoor Newcastle University Dr Alex HendersonNewcastle upon Tyne NHS Foundation Trust
Colorectal Cancer Prof Ian TomlinsonUniversity of Oxford Mohammad IlyasThe University of Nottingham
Haematological Malignancy Prof Anna Schuh University of Oxford Paresh VyasUniversity of Oxford
Lung Cancer Dr Charles SwantonThe Francis Crick Institute Prof Fiona BlackhallThe Christie NHS Foundation Trust
Neuroendocrine Tumours Chrissie ThirlwellUniversity College London
Ovarian and Endometrial Cancer Dr James BrentonNHS
Dr David ChurchUniversity of Oxford
Pan Cancer Prof Dion MortonUniversity Hospitals Birmingham
Glioma Prof Keyoumars Ashkan  King’s College Hospital NHS Foundation Trust
Upper gastrointestinal cancer Prof John Bridgewater – University College London
Renal cell carcinoma Dr James Larkin – Royal Marsden NHS Foundation Trust
Melanoma Dr Paul Lorigan– Christie NHS Foundation Trust
Testicular Cancer Dr Andrew Protheroe – Oxford University Hospitals NHS Foundation Trust
Cancer of Unknown Primary Dr Harpreet Wasan Imperial College London
Prostate Cancer Prof Johann de BonoInstitute of Cancer Research Dr Mark LinchUniversity College London
Renal Cell Carcinoma Dr James LarkinRoyal Marsden NHS Foundation Dr Anna KoziellKing’s College London
Sarcoma Prof Adrienne FlanaganUniversity College London
Head and Neck Cancer Prof Terry JonesUniversity of Liverpool
Matt Lechner – University College London
Liam Masterson – University of Cambridge
Cross Cutting Education and Training Maxine FosterNHS
Electronic Records Prof Harry HemingwayUniversity College London
Enabling Rare Disease Translational Genomics via Advanced Analytics and International Interoperability Prof Katherine BushbyNewcastle University
Dr Eamonn Sheridan – University of Leeds
Dr Michael SimpsonKing’s College London
Ethics and Social Science Prof Mike ParkerUniversity of Oxford
Functional Cross Cutting Prof Colin CooperUniversity of East Anglia
Dr Gkikas MagiorkinisUniversity of Oxford
Functional Effects Dr Ewan BirneyEuropean Bioinformatics Institute
Health Economics Dr Sarah WordsworthUniversity of Oxford Prof Ian TomlinsonUniversity of Oxford
Machine Learning, Quantitative Methods and Functional Genomics Prof Martin TobinUniversity of Leicester Diana Baralle University of Southampton
Population Genomics Dr Richard DurbinWellcome Trust Sanger Institute Jean-Baptiste CazierBirmingham University
Validation and Feedback Prof Bill NewmanManchester University Dominic McMullanBirmingham Women’s NHS Foundation Trust
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