Dr Ataf Sabir and Dr Sufyan Dogra talk about the challenges faced by British Muslims in genomics.
The Diverse Data vision
Our vision is that all patients, regardless of their background, receive the same quality of genomics-enabled personalised medicine, supported by the latest research on people like them.
Read and comment on a live version of our strategy to see our plans and input into our design.
What makes human genomes diverse?
Human genomes are 99.9% identical; however, it's differences in the 0.1% which make each of us unique – whether in terms of our hair colour, our like/dislike of certain foods, and even our sleeping patterns.
Variations in genomes can results from factors such as human migration patterns, our ancestry and choice of mate, and oftentimes environmental factors (which along with genetics, can contribute to a trait such as height and weight).
These variants tend to appear at different frequencies across different populations. Sometimes, they're rare and impact only specific families. At other times, the variants are common and can be found across populations.
People of European genetic ancestry represent ~80%
Some polygenic risk scores are ~4x
7% of significant associations
while only 2%
Our focus areas
We aim to create a world-leading genomic dataset and patient-designed research agenda for genomic sickle cell research.
Partnering with community groups and research studies to improve understanding of maternal inequalities, particularly preterm birth.
Equity in genomic medicine and research
We aim to embed equity into all the work that we do at Genomics England and support the wider ecosystem to do the same.
How we tackle our focus areas:
Research & discovery: Understand the data gap
Improve our understanding of genomic diversity by reviewing, stimulating and conducting research into diversity and its impacts on scientific, clinical and health system outcomes.
Community & engagement: Close the gaps, together
Convene and work with patient, genomic and data communities to design, develop and implement equity-enhancing strategies.
Sequencing & data: Fill the data gap
Increase the volume and depth of genomic data available on individuals from under-represented groups by sequencing genomes, and generating, linking and facilitating better access to data from diverse populations.
Products, tools, & behaviours: Bridge the data gap
Work with clinicians, analysts, researchers, patients, and community groups to develop tools, and processes to improve research, service-delivery practices, recruitment and care.
Latest blogs from the Diverse Data team
Often work is shared at the end and has a shiny, positive slant to it. Issues of data diversity can raise complex scientific, technical as well as social and emotional debates. The Diverse Data Initiative aims to share more during the process to show the journey, and hopefully encourage others to course direct. To learn more about how the team works, interim outputs and what we’re thinking, have a read of our blogs.