Research Seminar: Jayne Barbour and Máté Manczinger

The Genomics England Research Seminar series is a season of events held to demonstrate the best research from Genomics England and our partners. They started in October 2018, and are monthly, free-to-attend talks presented by Research Network members on the latest research being performed using data from the National Genomic Research Library.

This month's seminar speakers will be:

Jayne Barbour - 'A pan cancer analysis of mutations in CTCF-cohesin binding sites reveals a role for uracil incorporation and repair by XPD'

Somatic mutation densities are unevenly distributed across the genome and influenced by epigenetics. We performed a pan-cancer analysis of somatic mutation densities in CTCF-cohesin binding sites and found significant hotspots in cancer samples with driver mutations in nucleotide excision repair gene, XPD. In depth genome wide analysis showed remarkable redistribution of somatic mutations in cancers with XPD mutation and a novel association with genomic uracil incorporation. Jayne undertook her PhD in cellular metabolism under Nigel Turner at UNSW Sydney and has been working with Jason WH Wong in cancer genomics the last 6 years at the University of Hong Kong.

Máté Manczinger - 'Synergy of HLA class I and II shapes the strength of antitumor immune response'

Máté Manczinger is the leader of the Systems Immunology Research Group in the Biological Research Centre, Szeged, Hungary. His group focuses on the adaptive immune recognition of infectious agents and cancer. Specifically, they examine the role of HLA variability in infections (Manczinger et al., PloS Biology, 2019) and cancer (Manczinger et al., Nature Cancer, 2021). The group also aims to identify peptide characteristics associated with immunogenicity (Koncz et al., PNAS, 2021).

About the research seminars

The seminars will be held on the last Tuesday of each month at 2 to 3pm. These will be online sessions open to everyone and free to attend, we hope to have representation from across the Research Network, Discovery Forum and 100,000 Genomes Project participants as well as anyone else who would be interested in joining.

For updates on the seminars including announcements and speakers please follow the Genomics England twitter page. You can watch all previous Research Seminars on the Genomics England YouTube channel.

If you would like to present your research from the Genomics England Research Environment at one of these events please get in touch with the Research Management team at [email protected] and if you intend to publish on this research please include this so that we can publicise your paper on our Publications page.