Identifying novel treatments for Glioblastoma using Ex Vivo Screening
Academic research community (GECIP)
Academics, clinicians, and students worldwide can join our research community, the Genomics England Clinical Interpretations Partnership (GECIP, for short).
Already a member of GECIP?
Go to members' area
-
Breast cancer Cancer of unknown primary Childhood solid cancers Colorectal cancer Glioma Haematological malignancies Head and neck cancer Lung cancer Melanoma Neuroendocrine tumours Ovarian and endometrial cancer Pan cancer (across cancers) Prostate cancer Renal (kidney) cell carcinoma Sarcoma Testicular cancer Upper gastrointestinal cancer
Project Title
Project Lead Project DateResearch projects for Glioma
Glioma predisposition gene discovery
Identifying subtypes of Glioblastoma (GBM) patients via Network Approaches
Description of glioblastoma biomarkers in extracellular vesicles derived from patients’ blood
Quantifying subclonal evolutionary dynamics and intra-tumour heterogeneity
Using density of variants and mutational signatures to reconstruct chromatin accessibility maps
Measuring negative selection on essential genes and the immunopeptidome to assess immunoediting
Multi-omic profiling of glioma tumours
Elderly patients with glioblastoma
Determining the effects of adjuvant chemo/radiation therapy on glioma genomes
Identifying new molecular sub-types and pathways of glioma
Exploring the dynamics of extrachromosomal DNA drivers in gliomas
Genomic biomarkers of pseudoprogression
Predictive genomic biomarkers of transformation imaging phenotypes
Genomic and radiomic characteristics of glioma
Functional evaluation and interpretation of potential driver variants in glioma and follow-up analyses in additional data sets and model systems
Assessing the contribution of inherited variation to glioma risk
Genomic characterisation of unusual glioma cases
Integrating genomics and glioma clinical trials
Identification and characterisation of mitochondrial and viral genomes in glioma
Glioma research plan
Full details of the research proposed by this domain