Academics, clinicians, and students worldwide can join our research community, the Genomics England Clinical Interpretations Partnership (GECIP, for short).
Genomic and immunogenomic landscape of prostate cancer
Project Lead
Mark Linch
Project Date
18/11/2020
Lay Summary
Prostate cancer remains a leading cause of cancer death in men. The immune system is important for eradicating cancer and novel treatments are trying to harness the immune system for anti-tumour activity. However the immune landscape of early prostate cancer is not well understood. We aim to analyse the broad range of genetic variants that may impact anti-tumour immunity and with this information identify new treatment strategies, or optimise existing ones.
Prostate cancer remains a leading cause of cancer death in men. The immune system is important for eradicating cancer and novel treatments are trying to harness the immune system for anti-tumour activity. However the immune landscape of early prostate cancer is not well understood. We aim to analyse the broad range of genetic variants that may impact anti-tumour immunity and with this information identify new treatment strategies, or optimise existing ones.
Pan Prostate Consortium Analyses
Project Lead
Ros Eeles
Project Date
14/07/2021
Lay Summary
This is an international research project (Panprostate.org). The project aims to understand common and distinguishing patterns of variation among prostate cancer cases and controls without prostate cancer. We will first perform uniform computational processing of the whole genome sequencing data from the tumours and normal control DNA of more than 2000 donors. This will eliminate differences that are due to different ways of analysing the data. In collaboration with other researchers in the Pan Prostate Cancer Group, we will then address research questions relating to the types and subtypes of cancer, patterns of mutation in genes and their regulatory regions, large-scale structural changes in the genome, and the evolution of cancer cells, among others. These questions will be related to clinical outcomes among the tissue donors to this project. We should like to use the prostate cancer GeCIP data for validation analyses.
This is an international research project (Panprostate.org). The project aims to understand common and distinguishing patterns of variation among prostate cancer cases and controls without prostate cancer. We will first perform uniform computational processing of the whole genome sequencing data from the tumours and normal control DNA of more than 2000 donors. This will eliminate differences that are due to different ways of analysing the data. In collaboration with other researchers in the Pan Prostate Cancer Group, we will then address research questions relating to the types and subtypes of cancer, patterns of mutation in genes and their regulatory regions, large-scale structural changes in the genome, and the evolution of cancer cells, among others. These questions will be related to clinical outcomes among the tissue donors to this project. We should like to use the prostate cancer GeCIP data for validation analyses.
Prostate cancer research plan
Full details of the research proposed by this domain
