Genomic and immunogenomic landscape of prostate cancer
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Breast cancer Cancer of unknown primary Childhood solid cancers Colorectal cancer Glioma Haematological malignancies Head and neck cancer Lung cancer Melanoma Neuroendocrine tumours Ovarian and endometrial cancer Pan cancer (across cancers) Prostate cancer Renal (kidney) cell carcinoma Sarcoma Testicular cancer Upper gastrointestinal cancer
Project Title
Project Lead Project DateResearch projects for Prostate cancer
Pan Prostate Consortium Analyses
This is an international research project (Panprostate.org). The project aims to understand common and distinguishing patterns of variation among prostate cancer cases and controls without prostate cancer. We will first perform uniform computational processing of the whole genome sequencing data from the tumours and normal control DNA of more than 2000 donors. This will eliminate differences that are due to different ways of analysing the data. In collaboration with other researchers in the Pan Prostate Cancer Group, we will then address research questions relating to the types and subtypes of cancer, patterns of mutation in genes and their regulatory regions, large-scale structural changes in the genome, and the evolution of cancer cells, among others. These questions will be related to clinical outcomes among the tissue donors to this project. We should like to use the prostate cancer GeCIP data for validation analyses.
This is an international research project (Panprostate.org). The project aims to understand common and distinguishing patterns of variation among prostate cancer cases and controls without prostate cancer. We will first perform uniform computational processing of the whole genome sequencing data from the tumours and normal control DNA of more than 2000 donors. This will eliminate differences that are due to different ways of analysing the data. In collaboration with other researchers in the Pan Prostate Cancer Group, we will then address research questions relating to the types and subtypes of cancer, patterns of mutation in genes and their regulatory regions, large-scale structural changes in the genome, and the evolution of cancer cells, among others. These questions will be related to clinical outcomes among the tissue donors to this project. We should like to use the prostate cancer GeCIP data for validation analyses.
Prostate cancer research plan
Full details of the research proposed by this domain